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1

Drug Discovery in the Next Millennium

Ohlstein, Eliot H., Ruffolo Jr, Robert R., Elliott, John D.

Journal:

Annual Review of Pharmacology

Year:

2000

Language:

english

File:

PDF, 114 KB

english, 2000

2

New concepts in α-adrenoceptor pharmacology

Robert R. Ruffolo Jr., J. Paul Hieble

Journal:

Pharmacological Research

Year:

1995

Language:

english

File:

PDF, 161 KB

english, 1995

3

Endothelin receptors: Receptor classification, novel receptor antagonists, and potential therapeutic targets

Eliot H. Ohlstein, John D. Elliott, Giora Z. Feuerstein, Robert R. Ruffolo Jr.

Journal:

Medicinal Research Reviews

Year:

1996

Language:

english

File:

PDF, 1.79 MB

english, 1996

4

The interaction of the enantiomers of carvedilol with α1- and β1-adrenoceptors

Andrew J. Nichols, Anthony C. Sulpizio, Daryl J. Ashton, J. Paul Hieble, Robert R. Ruffolo Jr

Journal:

Year:

1989

Language:

english

File:

PDF, 596 KB

english, 1989

5

Characterization of the hemodynamic activities of fenoldopam and its enantiomers in the dog

Lewis B. Kinter, Eugene Horner, William A. Mann, Dr. Robert R. Ruffolo Jr., Joseph Weinstock

Journal:

Year:

1990

Language:

english

File:

PDF, 680 KB

english, 1990

6

Effects of catechol ring fluorination on cardiovascular and renal activities of fenoldopam enantiomers

Lewis B. Kinter, William A. Mann, Joseph Weinstock, Robert R. Ruffolo Jr.

Journal:

Year:

1994

Language:

english

File:

PDF, 971 KB

english, 1994

7

α-adrenoceptors: Recent developments

Robert R. Ruffolo Jr., Jeffrey M. Stadel, J. Paul Hieble

Journal:

Medicinal Research Reviews

Year:

1994

Language:

english

File:

PDF, 3.19 MB

english, 1994

8

Apoptosis: a potential target for discovering novel therapies for cardiovascular diseases

Tian-Li Yue, Eliot H Ohlstein, Robert R Ruffolo Jr

Journal:

Current Opinion in Chemical Biology

Year:

1999

Language:

english

File:

PDF, 755 KB

english, 1999

9

Chirality in α- and β-adrenoceptor agonists and antagonists

Robert R. Ruffolo Jr.

Journal:

Year:

1991

Language:

english

File:

PDF, 2.36 MB

english, 1991

10

Carvedilol: A Novel Cardiovascular Drug with Multiple Actions

Robert R. Ruffolo Jr., Duane A. Boyle, David P. Brooks, Giora Z. Feuerstein, Robert P. Venuti, Mary Ann Lukas, George Poste

Journal:

Cardiovascular Therapeutics

Year:

1992

Language:

english

File:

PDF, 2.39 MB

english, 1992

11

Carvedilol: A Novel Multiple Action Antihypertensive Drug that Provides Major Organ Protection

Giora Feuerstein, Tian-Li Yue, XinLiang Ma, Robert Ruffolo Jr.

Journal:

Cardiovascular Therapeutics

Year:

1994

Language:

english

File:

PDF, 1.25 MB

english, 1994

12

Effects of a hydroxylated metabolite of the β-adrenoreceptor antagonist, carvedilol, on post-ischaemic splanchnic tissue injury

Theodore A Christopher, Bernard L Lopez, Xin-Liang Ma, Giora Z Feuerstein, Robert R Ruffolo Jr, Tian-Li Yue

Journal:

British Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 326 KB

english, 1998

13

Antinociceptive activity of N-(4-hydroxyphenacetyl)-4-aminoclonidine, a novel analog of clonidine: Role of opioid receptors and alpha-adrenoceptors

Martin D. Hynes, Daphne Atlas, Robert R. Ruffolo Jr.

Journal:

Pharmacology Biochemistry and Behavior

Year:

1983

Language:

english

File:

PDF, 327 KB

english, 1983

14

Distribution and function of peripheral α-adrenoceptors in the cardiovascular system

Robert R. Ruffolo Jr.

Journal:

Pharmacology Biochemistry and Behavior

Year:

1985

Language:

english

File:

PDF, 842 KB

english, 1985

15

α-Adrenoceptors

Robert R. Ruffolo Jr., J.Paul Hieble

Journal:

Pharmacology & Therapeutics

Year:

1994

Language:

english

File:

PDF, 6.00 MB

english, 1994

16

Protective Effects of Carvedilol in the Myocardium

Giora Z Feuerstein MD, Antoine Bril PhD, Robert R Ruffolo Jr, PhD

Journal:

The American Journal of Cardiology

Year:

1997

Language:

english

File:

PDF, 81 KB

english, 1997

17

Comparison of bisoprolol and carvedilol cardioprotection in a rabbit ischemia and reperfusion model

Feng Gao, Jun Chen, Bernard L Lopez, Theodore A Christopher, Juanli Gu, Paul Lysko, Robert R Ruffolo Jr., Eliot H Ohlstein, Xin L Ma, Tian-Li Yue

Journal:

European Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 355 KB

english, 2000

18

Comparison of metoprolol and carvedilol pharmacology and cardioprotection in rabbit ischemia and reperfusion model

Giora Feuerstein, Gao-Lin Liu, Tian-Li Yue, H-Y Cheng, J.Paul Hieble, Jonathan R.S Arch, Robert R Ruffolo Jr., X.-L Ma

Journal:

European Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 340 KB

english, 1998

19

SB 211475, a metabolite of carvedilol, reduces infarct size after myocardial ischemic and reperfusion injury in rabbits

Harald Brunvand, Gaolin Liu, Xin-Liang Ma, Tian-Li Yue, Robert R Ruffolo Jr., Giora Z Feuerstein

Journal:

European Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 233 KB

english, 1998

20

Effects of α1-adrenoceptor antagonists on agonist and tilt-induced changes in blood pressure: relationships to uroselectivity

J.Paul Hieble, David C Kolpak, Gerald P McCafferty, Robert R Ruffolo Jr., Rodolfo Testa, Amedeo Leonardi

Journal:

European Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 302 KB

english, 1999

21

Apoptosis and Congestive Heart Failure

Giora Feuerstein, Robert R Ruffolo Jr., Tian-Li Yue

Journal:

Trends in Cardiovascular Medicine

Year:

1997

Language:

english

File:

PDF, 2.02 MB

english, 1997

22

L 1 - IMIDAZOLINE RECEPTORS: HISTORICAL PERSPECTIVE

J. Paul Hieble, Robert R. Ruffolo Jr.

Journal:

Fundamental & Clinical Pharmacology

Year:

1992

Language:

english

File:

PDF, 634 KB

english, 1992

23

Importance of receptor regulation in the pathophysiology and therapy of congestive heart failure

Robert R. Ruffolo Jr., Gregory A. Kopia

Journal:

The American Journal of Medicine

Year:

1986

Language:

english

File:

PDF, 648 KB

english, 1986

24

Biochemical correlates for the pharmacological effects of L(+)-Isomers and β-desoxy-sympathomimetic amines

Robert R. Ruffolo Jr., Duane D. Miller, Popat N. Patil

Journal:

Biochemical Pharmacology

Year:

1976

Language:

english

File:

PDF, 669 KB

english, 1976

25

Properties of 8,9-dichloro-2,3,4,5-tetrahydro-1H- 2-benzazepine, an inhibitor of norepinephrine N-methyltransferase

Ray W. Fuller, Susan Hemrick-Luecke, Richard E. Toomey, Jong-Sin Horng, Robert R. Ruffolo Jr., Bryan B. Molloy

Journal:

Biochemical Pharmacology

Year:

1981

Language:

english

File:

PDF, 777 KB

english, 1981

26

Receptor interactions of imidazolines influence of ionization constant on the diffusion of clonidine and a series of structurally related imidazolidines into and out of the central nervous system

Robert R. Ruffolo Jr., Emily L. Yaden, John S. Ward

Journal:

European Journal of Pharmacology

Year:

1982

Language:

english

File:

PDF, 670 KB

english, 1982

27

Selective α2-adrenoceptor agonist activity of the novel inotropic agent, ASL-7022: Comparison with dobutamine

Robert R. Ruffolo Jr., Emily L. Yaden

Journal:

European Journal of Pharmacology

Year:

1983

Language:

english

File:

PDF, 281 KB

english, 1983

28

Differences in the applicability of the Easson-Stedman hypothesis to the α1- and α2-adrenergic effects of phenethylamines and imidazolines

Robert R. Ruffolo Jr., Peter J. Rice, Popat N. Patil, Akihiko Hamada, Duane D. Miller

Journal:

European Journal of Pharmacology

Year:

1983

Language:

english

File:

PDF, 352 KB

english, 1983

29

Relative potency of LY141865 at dopamine DA2 and histamine H2 receptors

Robert R. Ruffolo Jr., Carl J. Shaar

Journal:

European Journal of Pharmacology

Year:

1983

Language:

english

File:

PDF, 133 KB

english, 1983

30

Systemic hemodynamic effects of dopamine, (±)-dobutamine and the (+)- and (−)-enantiomers of dobutamine in anesthetized normotensive rats

Robert R. Ruffolo Jr., Karen Messick

Journal:

European Journal of Pharmacology

Year:

1985

Language:

english

File:

PDF, 672 KB

english, 1985

31

Relationship between α2-adrenoceptor occupancy and response for B-HT 933 in canine saphenous vein

Robert R. Ruffolo Jr., Robert L. Zeid

Journal:

European Journal of Pharmacology

Year:

1985

Language:

english

File:

PDF, 361 KB

english, 1985

32

The relationship between alterations in α1-adrenoceptor reserve by phenoxybenzamine and benextramine and the sensitivity of cirazoline-induced pressor responses to inhibition by nifedipine

Andrew J. Nichols, Robert R. Ruffolo Jr.

Journal:

European Journal of Pharmacology

Year:

1986

Language:

english

File:

PDF, 379 KB

english, 1986

33

Characterization of α-adrenoceptors mediating sympathetic vasoconstriction in rat autoperfused hindlimb: Effects of SK&F 104078

Iain C. Medgett, Robert R. Ruffolo Jr.

Journal:

European Journal of Pharmacology

Year:

1987

Language:

english

File:

PDF, 344 KB

english, 1987

34

Inhibition of plasma choliesterase prevents the dopamine DA-l receptor mediated renal vasodilation produced by ibopamine

Andrew J. Nichols, Ronald J. Shebuski, Robert R. Ruffolo Jr.

Journal:

European Journal of Pharmacology

Year:

1987

Language:

english

File:

PDF, 282 KB

english, 1987

35

Effects of benzylic hydroxyl substitution on the α-adrenoceptor blocking activity of tolazoline

Robert R. Ruffolo Jr., Andrew J. Nichols, Popat N. Patil, Akihiko Hamada, Michael Clark, Duane D. Miller

Journal:

European Journal of Pharmacology

Year:

1988

Language:

english

File:

PDF, 370 KB

english, 1988

36

Differential effect of pertussis toxin on pre- and postjunctional α2-adrenoceptors in the cardiovascular system of the pithed rat

Andrew J. Nichols, Evangeline D. Motley, Robert R. Ruffolo Jr.

Journal:

European Journal of Pharmacology

Year:

1988

Language:

english

File:

PDF, 376 KB

english, 1988

37

Local cutaneous hemodynamic effects of carvedilol and labetalol in the anesthetized rat

Robert N. Willette, Charles F. Sauermelch, Robert R. Ruffolo Jr.

Journal:

European Journal of Pharmacology

Year:

1990

Language:

english

File:

PDF, 270 KB

english, 1990

38

Carvedilol, a new β-adrenoceptor antagonist and vasodilator antihypertensive drug, inhibits superoxide release from human neutrophils

Tian-Li Yue, Patrick J. McKenna, Robert R. Ruffolo Jr., Giora Feuerstein

Journal:

European Journal of Pharmacology

Year:

1992

Language:

english

File:

PDF, 293 KB

english, 1992

39

SB 211475, a metabolite of carvedilol, a novel antihypertensive agent, is a potent antioxidant

Tian-Li Yue, Patrick J. Mckenna, Paul G. Lysko, Juan-Li Gu, Kathryn A. Lysko, Robert R. Ruffolo Jr., Giora Z. Feurstein

Journal:

European Journal of Pharmacology

Year:

1994

Language:

english

File:

PDF, 660 KB

english, 1994

40

Carvedilol prevents low-density lipoprotein (LDL)-enhanced monocyte adhesion to endothelial cells by inhibition of LDL oxidation

Tian-Li Yue, Xinkang Wang, Juan-Li Gu, Robert R. Ruffolo Jr., Giora Z. Feuerstein

Journal:

European Journal of Pharmacology

Year:

1995

Language:

english

File:

PDF, 640 KB

english, 1995

41

Pharmacology of eprosartan, an angiotensin II receptor antagonist: Exploring hypotheses from clinical data

David P. Brooks, Eliot H. Ohlstein, Robert R. Ruffolo Jr.

Journal:

American Heart Journal

Year:

1999

Language:

english

File:

PDF, 172 KB

english, 1999

42

Recent Observations With β-Adrenoceptor Blockade: Beneficial Effects in Hypertension and Heart Failure

Robert R Ruffolo Jr., Giora Z Feuerstein, Eliot H Ohlstein

Journal:

American Journal of Hypertension

Year:

1998

Language:

english

File:

PDF, 123 KB

english, 1998

43

RECEPTOR INTERACTIONS OF IMIDAZOLINES: α-ADRENOCEPTORS OF RAT AND RABBIT AORTAE DIFFERENTIATED BY RELATIVE POTENCIES, AFFINITIES AND EFFICACIES OF IMIDAZOLINE AGONISTS

ROBERT R. RUFFOLO Jr., JAMES E. WADDELL

Journal:

British Journal of Pharmacology

Year:

1982

Language:

english

File:

PDF, 1.18 MB

english, 1982

44

Cardiovascular actions of a new selective postjunctional α.-adrenoceptor antagonist, SK&F 104856, in normotensive and hypertensive dogs

J. Paul Hieble, Andrew J. Nichols, Todd A. Fredrickson, P. Dennis DePalma, Robert R. Ruffolo Jr., David P. Brooks

Journal:

British Journal of Pharmacology

Year:

1992

Language:

english

File:

PDF, 930 KB

english, 1992

45

Comparison between carvedilol and captopril in rats with partial ablation-induced chronic renal failure

David P. Brooks, Brian G. Short, Matthew J. Cyronak, Lisa C. Contino, Martin DiCristo, Yi-Xin Wang, Robert R. Ruffolo Jr.

Journal:

British Journal of Pharmacology

Year:

1993

Language:

english

File:

PDF, 1.75 MB

english, 1993

46

Lactose sensitive lectin of chick retina and spinal cord

George S. Eisenbarth, Robert R. Ruffolo Jr., Frank S. Walsh, Marshall Nirenberg

Journal:

Biochemical and Biophysical Research Communications

Year:

1978

Language:

english

File:

PDF, 357 KB

english, 1978

47

Catecholamine content of pigmented and nonpigmented tissues of the rabbit

Robert R. Ruffolo Jr., P.N. Patil

Journal:

European Journal of Pharmacology

Year:

1974

Language:

english

File:

PDF, 233 KB

english, 1974

48

A kinetic analysis of a catechol-specific binding site in the microsomal fraction from the rabbit aorta

Robert R. Ruffolo Jr., Richard L. McCreery, Popat N. Patil

Journal:

European Journal of Pharmacology

Year:

1976

Language:

english

File:

PDF, 929 KB

english, 1976

49

Carvedilol, a new antihypertensive, prevents oxidation of human low density lipoprotein by macrophages and copper

Tian-Li Yue, Patrick J. McKenna, Paul G. Lysko, Robert R. Ruffolo Jr., Giora Z. Feuerstein

Journal:

Atherosclerosis

Year:

1992

Language:

english

File:

PDF, 702 KB

english, 1992

50

Metabolic regulation by α1- and α2-adrenoceptors

Robert R. Ruffolo Jr., Andrew J. Nichols, J. Paul Hieble

Journal:

Year:

1991

Language:

english

File:

PDF, 1.07 MB

english, 1991

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